Progressive APOBEC3B mRNA expression in distant breast cancer metastases

Progressive APOBEC3B mRNA expression in distant breast cancer metastases

BACKGROUND APOBEC3B was recently identified as a gain-of-function enzymatic source of mutagenesis, which may offer novel therapeutic options with molecules that specifically target this enzyme. In primary breast cancer, APOBEC3B mRNA is deregulated in a substantial proportion of cases and its expression is associated with poor prognosis. However, its expression in breast cancer metastases, whic...

Expression of APOBEC3B mRNA in Primary Breast Cancer of Japanese Women

Recent studies have identified the apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3B (APOBEC3B) as a source of mutations in various malignancies. APOBEC3B is overexpressed in several human cancer types, including breast cancer. In this study, we analyzed APOBEC3B mRNA expression in 305 primary breast cancers of Japanese women using quantitative reverse transcription-PCR, and in...

Zosteriform Skin Metastases from Breast Cancer

Metastatic skin cancer is a rare complication of internal malignancies.  Patients who develop cutaneous metastases rarely present with a zosteriform distribution.  Herein, we describe a 65-year-old woman with a prior history of breast cancer in whom zosteriform metastases developed along her left T8-9 abdominal dermatomes.

Elevated cyclooxygenase-2 expression correlates with distant metastases in breast cancer.

BACKGROUND Cyclooxygenase-2 (COX-2) overexpression clearly plays an important role in the pathogenesis of breast cancer. In this study, we analysed the relationship between COX-2 expression and various clinicopathological factors in human breast cancer. MATERIALS AND METHODS Using immunohistochemistry, we analysed archival specimens of human breast cancer (n=29) using antibodies to COX-2, ER,...

Skin metastases in breast cancer: a review article